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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: ADAMTS12 All Species: 8.18
Human Site: S236 Identified Species: 20
UniProt: P58397 Number Species: 9
    Phosphosite Substitution
    Charge Score: 0
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens P58397 NP_112217.2 1594 177676 S236 R H N L P S R S L S R R S I S
Chimpanzee Pan troglodytes XP_517836 1524 170558 S236 R H N L P S R S L S R R S I S
Rhesus Macaque Macaca mulatta XP_001090049 676 76654
Dog Lupus familis XP_536508 1351 150913 E88 R R D L A G P E D R A Y Y R I
Cat Felis silvestris
Mouse Mus musculus Q811B3 1600 177774 S240 R K T L R S R S L S R R S I S
Rat Rattus norvegicus Q1EHB3 1595 175796 R213 W E Q R Q Q K R R Q Q R S I S
Wallaby Macropus eugenll
Platypus Ornith. anatinus
Chicken Gallus gallus XP_424749 1118 125075
Frog Xenopus laevis
Zebra Danio Brachydanio rerio XP_001343371 949 105988
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster
Honey Bee Apis mellifera XP_396340 1195 134772
Nematode Worm Caenorhab. elegans Q19791 2150 242563 A269 E D V I E R K A R S R R A A N
Sea Urchin Strong. purpuratus
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 94.2 41.7 74.5 N.A. 80.4 44.9 N.A. N.A. 30.1 N.A. 35.3 N.A. N.A. 29 25.4 N.A.
Protein Similarity: 100 94.5 42.2 78.6 N.A. 87.5 60.9 N.A. N.A. 42.3 N.A. 46 N.A. N.A. 43.7 39.9 N.A.
P-Site Identity: 100 100 0 13.3 N.A. 80 26.6 N.A. N.A. 0 N.A. 0 N.A. N.A. 0 20 N.A.
P-Site Similarity: 100 100 0 20 N.A. 80 40 N.A. N.A. 0 N.A. 0 N.A. N.A. 0 53.3 N.A.
Percent
Protein Identity: N.A. N.A. N.A. N.A. N.A. N.A.
Protein Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Identity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 0 0 0 10 0 0 10 0 0 10 0 10 10 0 % A
% Cys: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % C
% Asp: 0 10 10 0 0 0 0 0 10 0 0 0 0 0 0 % D
% Glu: 10 10 0 0 10 0 0 10 0 0 0 0 0 0 0 % E
% Phe: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % F
% Gly: 0 0 0 0 0 10 0 0 0 0 0 0 0 0 0 % G
% His: 0 20 0 0 0 0 0 0 0 0 0 0 0 0 0 % H
% Ile: 0 0 0 10 0 0 0 0 0 0 0 0 0 40 10 % I
% Lys: 0 10 0 0 0 0 20 0 0 0 0 0 0 0 0 % K
% Leu: 0 0 0 40 0 0 0 0 30 0 0 0 0 0 0 % L
% Met: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % M
% Asn: 0 0 20 0 0 0 0 0 0 0 0 0 0 0 10 % N
% Pro: 0 0 0 0 20 0 10 0 0 0 0 0 0 0 0 % P
% Gln: 0 0 10 0 10 10 0 0 0 10 10 0 0 0 0 % Q
% Arg: 40 10 0 10 10 10 30 10 20 10 40 50 0 10 0 % R
% Ser: 0 0 0 0 0 30 0 30 0 40 0 0 40 0 40 % S
% Thr: 0 0 10 0 0 0 0 0 0 0 0 0 0 0 0 % T
% Val: 0 0 10 0 0 0 0 0 0 0 0 0 0 0 0 % V
% Trp: 10 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 0 0 0 0 0 0 0 0 0 10 10 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _